Study to understand mechanism of hemorrhagic stroke induced by oral bacteria

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14573
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: IHARA MASAFUMI 国立研究開発法人国立循環器病研究センター, 病院, 部長 (00372590)
• Co-Investigator(Kenkyū-buntansha): 仲野 和彦 大阪大学, 歯学研究科, 教授 (00379083) ; 齊藤 聡 国立研究開発法人国立循環器病研究センター, 病院, 医師 (40732996)
• Research Collaborator: SAITO Satoshi ; TONOMURA Shuichi
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 口腔内細菌 / ミュータンス菌 / 脳出血

Outline of Final Research Achievements

We investigated possible associations between collagen-bindin protein Cnm-positive Streptococcus mutans and cerebral hemorrhage. We enrolled 165 stroke patients who were assessed with brain MRI in the acute phase and found that those who had Cnm-positive Streptococcus mutans in the oral cavity had significantly greater nmumber of deep microbleeds in the brain. We are planning a prospective clinical research which will longitudinally evaluate possible increase of cerebral microbleeds to promote a new strategy of stroke prevention.

Free Research Field

臨床神経学