Development of photo-responsive biomaterials mimicking brain microenvironment

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14577
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ajioka Itsuki 東京医科歯科大学, 統合研究機構(脳統合機能研究センター), 准教授 (10348790)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 脳発生 / 生体適合性材料 / 微小環境

Outline of Final Research Achievements

In the development, the pathology, and the regeneration of the brain, a microenvironment plays an important role in regulating cellular functions by assembling specific extracellular matrix and growth factors. In this study, we aimed to develop an artificial scaffold mimicking the microenvironment and regulating cellular functions by photo-stimulation. We developed peptide-based scaffolds that are soluble in tube but form fiber after in vivo injection. We also developed peptide-based scaffolds immobilized light-sensitive protein.

Free Research Field

生体材料