Analysis of the importance and mechanisms of the nuclear positioning during neuritogenesis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14581
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Keio University
• Principal Investigator: Kuwako Ken-ichiro 慶應義塾大学, 医学部(信濃町), 訪問研究員 (30468475)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 神経細胞 / 核 / 樹状突起

Outline of Final Research Achievements

The LKB1 kinase was identified as a critical regulator of the nuclear localization of cerebellar Purkinje cells during neuritogenesis. Further analysis also uncovered that LKB1 was activated in developing Purkinje cells, and Purkinje cell-specific deletion of LKB1 severely disrupted the self-avoidance of Purkinje cell dendrites without affecting gross morphology. Through combinatorial analysis, the LKB1 downstream pathway that establishes the spatial configuration of Purkinje cell dendrites was determined. Together, this study indicates a possible link between the nuclear positioning and the dendrite morphogenesis.

Free Research Field

神経発生