Understanding mechanism of acidic pH induced tumor progression

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14605
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: The University of Tokyo
• Principal Investigator: Osawa Tsuyoshi 東京大学, 先端科学技術研究センター, 特任准教授 (50567592)
• Co-Investigator(Renkei-kenkyūsha): SHIMAMURA Teppei 名古屋大学, 大学院医学系研究科, 特任准教授 (00623943) ; KANKI Yasuharu 東京大学, アイソトープ総合センター, 助教 (00534869) ; SHIRAISHI Yuichi 東京大学, 医科学研究所, 助教 (70516880)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: がん微小環境 / 低pH / がん代謝 / 転写・代謝制御

Outline of Final Research Achievements

The tumor microenvironment plays an essential role in cancer progression, however, the mechanism of cancer progression induced by acidic pH microenvironment is still largely unknown. In this study, acidic pH cell culture system was established to identify the transcriptional-metabolic pathways for cancer progression under acidic pH tumor microenvironment.
As a result of this research, we established a simple model culture system to maintain acidic pH for at least 3 days and identified SREBP2 as a key transcriptional regulator under acidic pH using integration of comprehensive gene expression analysis and transcription factor motif analysis and we published our findings (Cell Reports, 2017).Moreover, accumulation and metabolic pathway specific to acidic pH are under investigation.

Free Research Field

腫瘍生物学