Elucidation of T cell infiltration mechanism into the tumor tissue by the antigen recognition

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14611
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology
• Research Institution: Kochi University
• Principal Investigator: Komatsu Toshihiro 高知大学, 教育研究部医療学系基礎医学部門, 助教 (90598517)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 血管内皮細胞 / 抗原提示 / 腫瘍抗原 / 細胞傷害性T細胞

Outline of Final Research Achievements

In this study, we found that cross-presentation of tumor antigen by tumor endothelial cells(tECs) promotes infiltration of tumor specific CTLs in tumors. We developed in vivo method to evaluate the infiltration of tumor specific CTLs in tumors by recognition of tumor antigen on tECs. We found that material “X” which promotes cross-presentation by tEC induced strong tumor regression.

Free Research Field

免疫学