2017 Fiscal Year Final Research Report
Studies on Crm1 that binds to Hox clusters
| Project/Area Number |
16K14676
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
OKA Masahiro 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 細胞核輸送ダイナミクスプロジェクト, プロジェクトリーダー (40432504)
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| Co-Investigator(Renkei-kenkyūsha) |
OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Crm1 / Hoxクラスター / 核外輸送因子 / 細胞分化 / クロマチン |
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| Outline of Final Research Achievements |
Our research revealed that the genome-wide binding pattern of Crm1, a nuclear export factor, dynamically changes during cell differentiation. Our work also suggests that the chromatin-bound Crm1 could interact with various proteins, including chromatin regulatory factors, and is possibly involved in the epigenetic regulation.
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| Free Research Field |
細胞生物学
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