2017 Fiscal Year Final Research Report
Understanding for Alzheimer's disease pathogenesis involved in ApoE4 and X11L genes by large scale of expression analysis of genes
| Project/Area Number |
16K14690
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | アルツハイマー病 / アポリポタンパク質 / 遺伝子発現制御 |
|---|
| Outline of Final Research Achievements |
ApoE4 is largest risk factor of Alzheimer's disease (AD) except for aging.Resent researches report a alternative gene expression in AD subjects of ApoE4 carriers compared to non-carriers.One of strong candidate to regulate ApoE gene expression is X11L gene that we identified previously. In this research using ApoE4-KI/X11L-KO mice, we analyzed gene-expression profiles, and we identified FXR-binding motif on genes involving in AD onset. Furthermore, we found that X11L regulates ApoE gene expression, which further regulates genes possessing FXR-binding motif, some of them may involve the pathogenesis of AD.
|
| Free Research Field |
神経生化学
|
