Studies on RNA degradation by autophagy for cell survival during starvation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14691
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional biochemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Suzuki Kuninori 東京大学, 大学院新領域創成科学研究科, 准教授 (20373194)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: オートファジー / オートファゴソーム / RNA分解 / 栄養飢餓 / 出芽酵母 / オートファジックボディ / RNA sequence

Outline of Final Research Achievements

When eukaryotic cells face with nutrient starvation, they degrade their cytoplasmic materials to adapt the severe environment. Recently, it has been reported that autophagy contributes to degrade RNA in response to starvation. In this study, we aimed to make a list of RNA species selectively degraded by autophagy. We have established an overexpression system of Atg15, which is responsible for the final step of autophagic degradation.

Free Research Field

細胞生物学