Role of glycans in control of FGF23 and Klotho functions

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14695
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional biochemistry
• Research Institution: Kyoto University
• Principal Investigator: Oka Shogo 京都大学, 医学研究科, 教授 (60233300)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: αKlotho / FGF23 / HNK-1糖鎖 / 腎臓 / グルクロン酸転移酵素

Outline of Final Research Achievements

αKlotho is predominantly expressed in kidney and has important roles in regulation of mineral metabolism including calcium. αKlotho is also known to act as a co-receptor for fibroblast growth factor 23 (FGF23). Mice lacking functional αKlotho protein exhibit phenotypes resembling human aging. α-Klotho is a type I membrane protein with two glucosidase-like domains in a extracellular region. It is, however, still unclear how these glucosidase-like domains are utilized for the klotho function since the essential glutamate residues for enzymatic activity are not conserved in αKlotho. In this study, we investigated the role of HNK-1 and its related glycans in the functional regulation for FGF23 and αKlotho.

Free Research Field

生化学　糖鎖生物学