2017 Fiscal Year Final Research Report
Germ cell-intrinsic function of sex chromosome in oogenesis
| Project/Area Number |
16K14740
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 卵母細胞 / 性染色体 |
|---|
| Outline of Final Research Achievements |
This study is aimed at understanding molecular mechanisms of sex chromosomes on oogenesis. Using an oocyte differentiation system, oocytes were produced from embryonic stem (ES) cells harboring XX, XY or XO chromosomes. The number of oocytes from XY and XO ES cells was much fewer than those from XX ES cells. Detail analyses demonstrated that the reasons of attenuated oocyte production from XO and XY ES cells were (1) mispairing of the sex chromosome during meiotic prophase I, (2) lower dosage of X chromosome, (3) a negative impact of a gene on Y chromosome. We identified a novel function of the Y-linked gene on meiotic progression. These results contribute to understanding of reasons why oocyte production is attenuated in patients with sex chromosome disorder.
|
| Free Research Field |
生殖生物学
|
