2017 Fiscal Year Final Research Report
Regulation of circadian clock of the eukaryotic host cell by the chloroplast and its evolution
| Project/Area Number |
16K14791
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 細胞内共生 / 細胞内時計 / 光合成 |
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| Outline of Final Research Achievements |
Chloroplasts were established through predation and temporary retention of photosynthetic prey and then as a facultative and permanent endosymbiotic relationship with photosynthetic organisms by a unicellular eukaryotic host cell. In this study, we investigated the mechanism regulating the host cell by the chloroplast and its evolution. We found that, in a unicellular red alga, photosynthetic activity in the chloroplast resets the circadian clock of the eukaryotic host cell through reducing power. In addition, we found that three species of amoebae feeding on photosynthetic prey are exposed to oxidative stress upon illumination. That stress decreased phagocytic uptake of prey whereas accelerated digestion of prey. These results suggest that there is a signal transduction mechanism by which reducing power generated by the chloroplast modulates eukaryotic host cell and that such mechanism has evolved from that in eukaryotes feeding on photosynthetic prey.
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| Free Research Field |
進化細胞生物学
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