2017 Fiscal Year Final Research Report
Identification of molecules that increase in response to bile acid supplementation and Involvement of those in life style-related diseases
| Project/Area Number |
16K14917
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清水 英寿 島根大学, 生物資源科学部, 准教授 (10547532)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 胆汁酸 |
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| Outline of Final Research Achievements |
Excess energy intake during aging enhances bile acid secretion from liver to intestinal lumen. Several symptoms are developed by the diet supplemented with cholic acid to mimic that condition accompanied by alteration of bile acid metabolism in organs and blood. We investigated bile acid metabolism to find responsible molecular species of bile acid for development of the symptoms observed in the cholic acid supplementation. Consequently, the cholic acid supplementation is involved in lipid accumulation via modulation of sterol metabolism by increase mainly in deoxycholic acid and taurocholic acid.
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| Free Research Field |
食品栄養学
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