2017 Fiscal Year Final Research Report
Study on sensing mechanism of low-digestible saccharides in nutrient-sensing enteroendocrine cells
Project/Area Number |
16K14918
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Hokkaido University |
Principal Investigator |
Hara Hiroshi 北海道大学, 農学研究院, 教授 (70198894)
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Co-Investigator(Kenkyū-buntansha) |
比良 徹 北海道大学, 農学研究院, 講師 (10396301)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | 難消化性糖質 / GLP-1 / アルロース / 難消化性デキストリン / GIP |
Outline of Final Research Achievements |
We examined the effects of indigestible saccharides including rare sugar D-allulose on a gut hormone GLP-1 secretion. Single oral administration of resistant maltodextrin (RMD) or D-allulose potently stimulated GLP-1 secretion in rats. D-allulose had larger and continuous stimulatory effect on GLP-1 secretion than RMD. The GLP-1-stimulating effect was observed by oral and luminal but not by intraperitoneal administration of D-allulose, indicating D-allulose exerted the effect in the intestinal lumen. These results demonstrate important role of enteroendocrine cell to sense indigestible saccharides in gut hormone secretions under a physiological condition.
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Free Research Field |
栄養生理学
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