The preventive effects of lutein and catechin on locomotive syndrome.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K14921
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: MIYAURA CHISATO 東京農工大学, 工学(系)研究科(研究院), 教授 (20138382)
• Co-Investigator(Kenkyū-buntansha): 平田 美智子 東京農工大学, 工学(系)研究科(研究院), 講師 (40544060)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ロコモティブシンドローム

Outline of Final Research Achievements

The aim of this study is the usage of food-derived components to prevent the locomotive syndrome (LOCOMO: Motor instrument syndrome) in middle-aged and aged persons. LOCOMO is caused by the decrease in motor function, aging, bone loss and muscle atrophy. Using tail suspension mice, the bone density was measured by DEXA, and the bone and muscle morphology were measured by three-dimensional micro-CT. We established the LOCOMO model to evaluate motor function using a live mouse. Using the LOCOMO model, we found that lutein recover the bone loss induced by tail suspension. Lutein was applied for mass identification using imaging mass spectrometry (iMS), and we identified the lutein molecule and its imaging. Our data may be useful for the development of functional foods using lutein to prevent LOCOMO.

Free Research Field

栄養生理学