2017 Fiscal Year Final Research Report
Induction of diabetes by CRTC1 deficiency
| Project/Area Number |
16K14925
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Montminy Marc Salk Institute, Professor
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 糖尿病 / 高脂肪食 / 転写因子 |
|---|
| Outline of Final Research Achievements |
We studied the induction mechanism of diabetes in CRTC1 knockout mouse. We found that High fat diet (HFD) induced severe hyperglycemia, hyperinsulinemia and insulin resistance in CRTC1KO mice. Furthermore, HFD elicited fatty liver, lipodystrophy and inflammation in visceral adipose tissue in CRTC1 KO mice. Tranplantation of adipose tissue from Wild type animal into CRTC1 KO mice successfully cured diabetes. These results indicate that HFD may activate CRTC1 in adipose tissue, suppressing inflammation. Also, CRTC1 may regulate gene expression related to glucose homeostasis.
|
| Free Research Field |
栄養化学
|
