Production of fatty liver in culled layer-chicken-manipulation of hepatic lipid metabolism in chicken

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15024
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Animal production science
• Research Institution: Kyoto University
• Principal Investigator: Matsui Tohru 京都大学, 農学研究科, 教授 (40181680)
• Co-Investigator(Kenkyū-buntansha): 友永 省三 京都大学, 農学研究科, 助教 (00552324) ; 白石 純一 日本獣医生命科学大学, 応用生命科学部, 助教 (50632345)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ニワトリ / 脂肪肝 / メチオニン / コリン / フルクトース / ビタミンE

Outline of Final Research Achievements

Fatty liver is incidentally induced in chicken, which is much-prized delicacy. We investigated the effect of nutritional manipulation on lipid content in the liver of culled layer-chicken.
Low methionine and low choline diet did not affect free methionine and choline concentrations in plasma, and hepatic lipid content, suggesting that the low methionine and low choline diet did not induce methionine and choline shortage in culled layer-chicken. High fructose diet did not affect hepatic lipid content. However, this diet increased mannitol content in the liver, suggesting that intestinal microbes produce mannitol from fructose and the absorbed mannitol accumulates in the liver. Because severe inflammation is frequently observed in the liver, we also investigated the effect of vitamin E supplementation on the induction of hepatic inflammation. However, vitamin E supplementation did not affect hepatic inflammation.

Free Research Field

動物栄養学