The molecular mechanism of transgenerational epigenetic inheritance

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15053
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: Nagoya University
• Principal Investigator: Hondo Eiichi 名古屋大学, 生命農学研究科, 教授 (30271745)
• Co-Investigator(Kenkyū-buntansha): 大松 勉 東京農工大学, 農学部, 准教授 (60455392)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 獲得形質 / エピゲノム / 糖尿病モデル

Outline of Final Research Achievements

This study aimed to clarify the molecular mechanism of transgenerational epigenetic inheritance. The miRNAs upregulated in the culture medium of pancreatic beta cell line were consistent with the miRNA species upregulated in the blood of diabetic mice. This suggests that miRNAs produced in degenerating beta cells should enter blood stream and have an influence on the germ cells. The methylated DNA regions of diabetic mice sperm in the previous report were not consistent with our result using our inbred strain of mice. Then, we revealed the epigenomic profile in glycometabolic genes using our own mice.

Free Research Field

動物形態学