2017 Fiscal Year Final Research Report
Secretion-factor-dependent mechanisms regulating transposable elements in the early mouse embryo
| Project/Area Number |
16K15054
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | レトロトランスポゾン / 転移因子 / インターロイキン / 全能性 / 多能性 |
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| Outline of Final Research Achievements |
Transposable elements are dispersed throughout the mammalian genome. Appropriate regulation of these elements is indispensable for the survival of the embryos/fetuses. In this study, using the mouse system, I found that the application of the IL17, one of the interleukin family members, to the cells could repress their transcription. Furthermore, I identified an IL17D receptor responsible for the immobilization of the transposable elements and the downstream signaling pathways as well. In the absence of IL17D signaling pathways, apoptosis signals are concomitantly upregulated, thereby cells with low quality are removed for supporting the proper embryonic development.
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| Free Research Field |
分子遺伝学
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