2017 Fiscal Year Final Research Report
Challenge toward controlling oxidative phenol coupling reaction by AZADO-Cu cooperative catalysis
| Project/Area Number |
16K15096
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 触媒・化学プロセス / 協奏触媒 / 空気酸化 / フェノール酸化 / 精密有機合成 / 有機ニトロキシルラジカル |
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| Outline of Final Research Achievements |
On the basis of our original aerobic catalytic alcohol oxidation system consisting of AZADO/CuCl/bipyridy/DMAP, we have challenged to discover another catalytic system that enables highly chemo- and regioselective phenol coupling reactions. As a result, we identified that combination of AZADO-Cr promoted an intramolecular coupling of 3-(3-(4-hydroxyphenyl)propyl)phenol to give the corresponding tricyclic product. We also disclosed that AZADO/CuCl/bipyridyl/DMAP system realized a highly chemoselective aerobic oxidation of sulfide-containing alcohols, providing a useful addition to AZADO oxidation technology.
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| Free Research Field |
化学系薬学
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