Development of Novel Synthetic Methods of Fused-heterocyclic Systems by Domino-type Cycloaddition of o-Xylylene Intermediate

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15098
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Matsuya Yuji 富山大学, 大学院医学薬学研究部(薬学), 教授 (50255858)
• Research Collaborator: KOHYAMA Aki ; KORESAWA Eri
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ドミノ型環化 / ベンゾシクロブテン

Outline of Final Research Achievements

For the purpose of construction of fused-heterocyclic systems by means of successive electrocyclic reactions of benzocyclobutene derivatives, We successfully synthesized nitron-substituted and nitro-substituted benzocyclobutene derivatives as a potential substrate. Thermal domino-cyclizations were investigated using these derivatives as a substrate, and it was found that the nitron derivatives did not react even under 180°C conditions and the nitro derivatives were hydrolyzed after ring-opening. Thus these compounds were not suitable for the substrates of planned domino-type cycloaddition reactions.

Free Research Field

有機合成化学