Development of fluorescent probe for detection of reductive stress

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15109
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Physical pharmacy
• Research Institution: Kyushu University
• Principal Investigator: Yamada Ken-ichi 九州大学, 薬学研究院, 教授 (60346806)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 薬学 / 分析科学 / ストレス

Outline of Final Research Achievements

In development of many oxidative disease, change of redox reaction have been reported to be involved. Here, in this study, we aimed to develop a detection probe for reductive stress. We herein designed a mitochondrial targeting profluorescent nitroxide probe for the detection of reductive stress. We demonstrated that this probe can detect an excess amount of electron donating compound in living cell, which causes the mitochondrial reductive stress.

Free Research Field

生物物理化学