Post-translational modifications of a mitochondria-resident protein and its role in systemic regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15115
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: ICHIJO Hidenori 東京大学, 大学院薬学系研究科(薬学部), 教授 (00242206)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ミトコンドリア / PGAM5 / 翻訳後修飾 / 代謝制御

Outline of Final Research Achievements

Mitochondria is indispensable for energy metabolism within the cell, which is also essential for whole-body energy metabolism. PGAM5, a mitochondria-resident protein, has newly clarified as a metabolism regulator in brown adipocytes. PGAM5 somehow senses environmental stresses and conveys signals into the nucleus resulting in the alteration of transcriptome, which includes the suppression of several thermogenic genes. We hereby discovered a novel mechanism that a mitochondria-resident protein regulates mitochondrial energy metabolism through the gene expression regulation in the nucleus.

Free Research Field

生化学、分子生物学