2017 Fiscal Year Final Research Report
Genetic tools for circuit-based drug discovery
| Project/Area Number |
16K15125
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Shuji 京都大学, 大学院薬学研究科, 教授 (60177516)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | ウイルスベクター / セロトニン |
|---|
| Outline of Final Research Achievements |
Neural transmission is achieved through three steps of biological processes. Depolarization and firing at cell somata, propagation of action potential, and release of neurotransmitters from nerve terminals. Different from other types of neurons, serotonin neurons and dopamine neurons release their transmitters from cell somata. However, physiological significance of this type of transmitter release is still unknown. In this research, we established viral-vector based platform for expressing miniSOG, a genetic tool for photo-inducible organelle inactivator, specifically in serotonin neurons.
|
| Free Research Field |
神経薬理学
|
