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2017 Fiscal Year Final Research Report

Dementia and gut microbiota

Research Project

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Project/Area Number 16K15132
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Natural medicines
Research InstitutionOsaka City University

Principal Investigator

TOMIYAMA Takami  大阪市立大学, 大学院医学研究科, 准教授 (10305633)

Co-Investigator(Renkei-kenkyūsha) UMEDA Tomohiro  大阪市立大学, 大学院医学研究科, 助教 (70549790)
Project Period (FY) 2016-04-01 – 2018-03-31
KeywordsGut microbiota / Dementia / Alzheimer's dsease / Antibiotic / Fecal transplantation / Herb extract / Model mouse / Memory
Outline of Final Research Achievements

To investigate possible relationship between dementia and gut microbiota, we examined cognitive function of our model mice (OSK-KI mice) after 1-month oral administration of antibiotics, fecal extracts, and anti-dementia herb extract Ekc-1. Antibiotic treatment and fecal transplantation influenced mouse memory, suggesting cognition is affected by gut microbiota. The beneficial effects of Ekc-1 on memory was partially cancelled by simultaneous antibiotic treatment, implying anti-dementia effects of Ekc-1 is, at least in part, mediated by gut microbiota. We analyzed gut microbiota in our different model mice (APP x tau double Tg mice) after 1-month Ekc-1 oral treatment. We found some differences between Tg and non-Tg mice, and Ekc-1 appeared to shift the balance of microbiota toward non-Tg mice. Subcutaneous administration of Ekc-1 little improved mouse memory. Our findings suggest that gut microbiota affects cognitive function, and its modification could be a treatment for dementia.

Free Research Field

神経科学

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Published: 2019-03-29  

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