2017 Fiscal Year Final Research Report
Dementia and gut microbiota
Project/Area Number |
16K15132
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Natural medicines
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Research Institution | Osaka City University |
Principal Investigator |
TOMIYAMA Takami 大阪市立大学, 大学院医学研究科, 准教授 (10305633)
|
Co-Investigator(Renkei-kenkyūsha) |
UMEDA Tomohiro 大阪市立大学, 大学院医学研究科, 助教 (70549790)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | Gut microbiota / Dementia / Alzheimer's dsease / Antibiotic / Fecal transplantation / Herb extract / Model mouse / Memory |
Outline of Final Research Achievements |
To investigate possible relationship between dementia and gut microbiota, we examined cognitive function of our model mice (OSK-KI mice) after 1-month oral administration of antibiotics, fecal extracts, and anti-dementia herb extract Ekc-1. Antibiotic treatment and fecal transplantation influenced mouse memory, suggesting cognition is affected by gut microbiota. The beneficial effects of Ekc-1 on memory was partially cancelled by simultaneous antibiotic treatment, implying anti-dementia effects of Ekc-1 is, at least in part, mediated by gut microbiota. We analyzed gut microbiota in our different model mice (APP x tau double Tg mice) after 1-month Ekc-1 oral treatment. We found some differences between Tg and non-Tg mice, and Ekc-1 appeared to shift the balance of microbiota toward non-Tg mice. Subcutaneous administration of Ekc-1 little improved mouse memory. Our findings suggest that gut microbiota affects cognitive function, and its modification could be a treatment for dementia.
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Free Research Field |
神経科学
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