Structure-toxicity relationship of designer drug having phenethylamine moiety

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15147
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Hiroshima University
• Principal Investigator: KOTAKE YAICHIRO 広島大学, 医歯薬保健学研究院(薬), 准教授 (20335649)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: 危険ドラッグ / 構造毒性相関 / フェネチルアミン

Outline of Final Research Achievements

We synthesized candidates of designer drugs having phenethylamine moiety and examined methamphetamine-related in vitro and in vivo activities. As a result, we found the particular compound having strong dopamine uptake inhibitory activity, locomotor activity, and dependency.

Free Research Field

衛生薬学