2017 Fiscal Year Final Research Report
Amino acid transporter-based drug development for cerebral creatine deficiency syndrome
| Project/Area Number |
16K15153
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
立川 正憲 東北大学, 薬学研究科, 准教授 (00401810)
吉田 将人 東北大学, 薬学研究科, 助教 (80511906)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 血液脳関門 / クレアチントランスポーター |
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| Outline of Final Research Achievements |
The purpose of the present study was to establish the basis of creatine prodrug therapy for cerebral creatine deficiency with creatine transporter (CRT/SLC6A8) defect. Protein expression of transporters as the potent brain drug delivery pathways was clarified in developing rat blood-brain barrier based on quantitative targeted absolute proteomics. The patient-derived fibroblasts exhibited the cellular transport of the chemically synthesized creatine prodrug followed by the creatine generation.
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| Free Research Field |
薬物送達学
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