2017 Fiscal Year Final Research Report
Development of an animal model of Stevens-Johnson syndrome induced by drugs.
| Project/Area Number |
16K15154
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA NAOYUKI 筑波大学, 医学医療系, 教授 (60231437)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ヒトの薬物動態・代謝予測系 / 皮膚薬剤過敏症 |
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| Outline of Final Research Achievements |
Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening drug adverse effects and are associated with human leukocyte antigen (HLA). Established animal models of Stevens-Johnson syndrome are using graft versus host effects. Thus, it was tried to develop an animal model of Stevens-Johnson syndrome induced by carbamazepine. Stevens-Johnson syndrome was not induced with carbamazepine in the transgenic mouse of HLA-A*31:01, a susceptibility allele for carbamazepine-induced Stevens-Johnson syndrome. The treatment with Poly (I:C) or irradiation did not enhance the development of Stevens-Johnson syndrome in the transgenic mouse of HLA-A*31:01.
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| Free Research Field |
医歯薬学
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