Controlling of the ion channel clustering and collective function by photoresponsive DNA

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15178
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Kanazawa University (2017); University of Fukui (2016)
• Principal Investigator: Sumino Ayumi 金沢大学, 新学術創成研究機構, 助教 (80717140)
• Co-Investigator(Kenkyū-buntansha): 神谷 由紀子 名古屋大学, 工学研究科, 准教授 (00527947)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: イオンチャネル / 光応答性DNA

Outline of Final Research Achievements

Recently, we have focused on the relationship between clustering and dispersion of ion channels and its functions. In this study, we have controlled the distance between channels by using photoresponsive DNA as a crosslinking agent for ion channels. By designing DNA with an appropriate sequence, we succeeded in controlling the distance between channels at room temperature.

Free Research Field

生物物理学