2017 Fiscal Year Final Research Report
Diagnosis of stress using the microRNA instead of amylase in saliva
| Project/Area Number |
16K15192
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Meikai University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | マイクロRNA / ストレス / 唾液腺 / 唾液 |
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| Outline of Final Research Achievements |
Saliva amylase is used as a stress marker, however it is secreted by various taste stimulations without stress, therefore we have a doubt in amylase as a stress marker. I investigated a new diagnostic method using the microRNA of salivary gland and saliva as a stress marker exchange from amylase. It is known that antistress hormone increased when a hypothalamus recognized stress. When mice were administrated to make essential condition of stress, microRNA(miR-141, 21a, 29b) of the salivary gland increased. These three microRNA did not change for the transient strain of the sympathetic nerve by epinephrine administration. Thus, these microRNAs become a marker of the essential stress when the organization collection such as biopsies is possible. On the other hand, it was very difficult to make a diagnosis of stress using the microRNA of saliva of the mouse and Homo sapiens, because of big standard deviation.
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| Free Research Field |
口腔生理学
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