2017 Fiscal Year Final Research Report
Study of the mechanism of biosynthesis of polysulfurated proteins coupled with translation
| Project/Area Number |
16K15208
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤井 重元 東北大学, 医学系研究科, 准教授 (00325333)
井田 智章 東北大学, 医学系研究科, 助教 (70570406)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | タンパク質ポリサルファ化 / システインポリスルフィド / システイン-tRNA合成酵素 / 活性イオウ分子種 |
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| Outline of Final Research Achievements |
Polysulfur is reactive persulfide species which have extra sulfur atoms in cysteine thiol and cellular proteins contain polysulfur abundantly (protein polysulfuration). In this study, we investigated the translation-coupled mechanism of protein polysulfuration mediated by cysteinyl-tRNA synthetase (CARS) and its biological functions. CARSs from various biological species including bacteria and mammals are found to have cysteine persulfide-producing activity and to be critically involved in protein polysulfuration. Protein polysulfuration is suggested to play important roles in the regulation of cellular function such as mitochondrial morphogenesis.
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| Free Research Field |
生化学
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