2017 Fiscal Year Final Research Report
Novel regulatory mechanisms of the intestinal immunity via the microvilli of intestinal epithelial cells
| Project/Area Number |
16K15219
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 腸上皮細胞 / 微絨毛 / 腸管免疫 / チロシンホスファターゼ / 腸内細菌 |
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| Outline of Final Research Achievements |
SAP-1, a receptor-type protein tyrosine phosphatase that is specifically expressed in intestinal epithelial cells, likely participates in the regulation of intestinal immunity by controlling the tyrosine phosphorylation level of its ligand CEACAM20. In this study, the regulatory mechanisms of SAP-1/CEACAM20-function and -expression were analyzed in vitro and in vivo. I showed a part of regulatory mechanisms of SAP-1/CEACAM20-mediated intestinal immunity.
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| Free Research Field |
生化学・分子生物学
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