2017 Fiscal Year Final Research Report
Role of MITOL in Alzheimer's disease
| Project/Area Number |
16K15224
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
YANAGI Shigeru 東京薬科大学, 生命科学部, 教授 (60252003)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | ユビキチンリガーゼ |
|---|
| Outline of Final Research Achievements |
Although mitochondrial ubiquitin ligase MITOL is suggested as a risk factor for Alzheimer's disease (AD), implication of MITOL in the pathology of AD is unknown. Here we generated and analyzed neuron-specific MITOL-knockout AD model mice. We found that MITOL knockout increases high toxic soluble amyloid-beta, resulting in exacerbation of symptoms of AD. This result suggests that MITOL regulates aggregation or conformation of amyloid-beta, thereby attenuating cytotoxicity of amyloid-beta.
|
| Free Research Field |
生化学
|
