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2017 Fiscal Year Final Research Report

Analysis of stealth antigens for developing tumor immunotherapy

Research Project

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Project/Area Number 16K15244
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionAsahikawa Medical College

Principal Investigator

Kobayashi Hiroya  旭川医科大学, 医学部, 教授 (90280867)

Co-Investigator(Kenkyū-buntansha) 小坂 朱  旭川医科大学, 医学部, 助教 (40561030)
大栗 敬幸  旭川医科大学, 医学部, 講師 (70564061)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywordscancer vaccines
Outline of Final Research Achievements

We found several stealth antigens which are epigenetically suppressed in tumor cells due to their high antigenicity and re-transcripted and -translated by treating with DNA methyltransferase inhibitor. We found that the stealth antigen-specific Th cells were efficiently generated from peripheral blood mononuclear cells from healthy donors. Also combination therapy of the Th cells and DNA methyltransferase inhibitor efficiently inhibited growth of human cancer cell line in immunodeficient mice.

Free Research Field

腫瘍免疫、病理

URL: 

Published: 2019-03-29   Modified: 2020-03-30  

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