Secretory Transcribed-ultraconserved regions in gastrointestinal and urological cancers and their application to liquid biopsy

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15247
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI WATARU 広島大学, 医歯薬保健学研究科(医), 教授 (40191118)
• Co-Investigator(Renkei-kenkyūsha): OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 分泌型T-UCR / 非翻訳RNA / 消化管癌 / 泌尿器癌 / リキッドバイオプシー

Outline of Final Research Achievements

Up-regulated transcribed ultraconserved region (T-UCR) transcripts in gastrointestinal cancers and urological cancers, such as U.63+, Uc.416+A, were found to be caidiate marker for liquid biopsy. Concerning prostate cancer, Uc.416+A in the blood was significantly higher in cases with metastases, with castration resistance (CRPC), and with docetaxel resistance. We also identified that Uc.249+A, Uc.266+A, etc. might regulate cancer stem cell properties of colorectal cancer.

Free Research Field

医歯薬学