2017 Fiscal Year Final Research Report
Elusidation of regulatory mechanism for regulatory Tcells by Arl8b
| Project/Area Number |
16K15253
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 全身性エリトマトーデス / Toll-like receptor 7 / 自己免疫疾患 / Arl8b |
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| Outline of Final Research Achievements |
I revealed that a small G protein Arl8b is associated with TLR7 and regulates TLR7 function. So, I analyzed several SLE mouse models. In some SLE mouse models, I analyzed the role of Arl8b on MRL/lpr mouse model. I observed that Arl8b plays an essential role for the development of SLE in this model. Because MRL/lpr mouse model is not much dependent on TLR7 function, I analyzed carefully TLR7 independent mechanism. I observed that regulatory T cells significantly increased in spleen of MRL/lpr Arl8b deficient mice compared with MRL/lpr wild type mice. IL-2 controls regulatory T cells. I observed IL-2 receptor expression level in spleen of MRL/lpr Arl8b deficient mouse. I found that IL-2 receptor expression level is significantly high on MRL/lpr Arl8b deficient T cells. I will analyze the role of Arl8b for IL-2 receptor expression and controlling regulatory T cell.
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| Free Research Field |
炎症免疫学
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