2016 Fiscal Year Final Research Report
Fetal microchimerism and cancer
| Project/Area Number |
16K15261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Keywords | キメラリズム / 妊娠 / 蛍光蛋白質 |
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| Outline of Final Research Achievements |
Fetal chimerisim is defined as the fetal cell migration into the mother during the pregnancy. We here addressed the hypothesis that migrated fetal cells become malignant in the mother. Crossing the male GFP (green fluorescent protein) transgenic mouse and the wild-type female mouse, we will try to identify the GFP-positive cells in the mother. After confirming the GFP cells, we will treat the mother with chemicals to induces inflammation/cancer. If this hypothesis is proven, we could propose the novel criteria of malignancy, novel strategies for diagnosis and treatment. From the view of experiment design, we could follow the cancer cells from the very early stage, which is useful to investigate the relationship between the interstitial cells and cancer.
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| Free Research Field |
実験病理学
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