2017 Fiscal Year Final Research Report
The interaction between host and ebolavirus
| Project/Area Number |
16K15283
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | エボラウイルス / グリコプロテイン / エントリー / 免疫逃避 |
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| Outline of Final Research Achievements |
When ebolavirus enter host cells, ebolavirus glycoprotein (Ebo-GP) associates with host receptors. We identified a new entry receptor EGPR on the surface of host cells. We also found that glycans on Ebo-GP are required for the binding of EGPR to Ebo-GP. Furthermore, EGPR enhances the infectivity of all 5 subgenus of ebolavirus that are known to infect human. We also analyzed EGPIM expressed on the NK cells that attack and remove viruses in the host. We discovered that Ebo-GP inhibits the binding of EGPIM to the ligand, which suggests a mechanism that ebolavirus the evade from cytotoxicity by NK cells.
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| Free Research Field |
ウイルス学
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