2017 Fiscal Year Final Research Report
Regulation of influenza protective antibody responses by microbiota
| Project/Area Number |
16K15296
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
八村 敏志 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40238019)
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| Co-Investigator(Renkei-kenkyūsha) |
Onodera Taishi 国立感染症研究所, 免疫部, 主任研究官 (90513143)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | インフルエンザ / 腸内細菌 |
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| Outline of Final Research Achievements |
In this study, we have investigated cross-reactivity of influenza hemagglutinin-binding monoclonal antibody panel to microbiota and identified several HA-binding monoclonal antibodies that are reactive to particular microbiota. Germline-reverted forms of antibodies possessed the cross-reactivity, indicating that the reactivity was already acquired in pre-immune status. Removal of microbiota using germ-free mice or antibiotics-treated mice elucidated the possible links between antigen-driven B cell development and microbiota. Thus, microbiota shapes the antibody repertoires to influenza viruses in both pre-immune and post-immune status.
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| Free Research Field |
感染免疫学
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