Investigation of molecular mechanism underly increased cAMP production by molecular hydrogen

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15315
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Chiba University
• Principal Investigator: Matsumoto Akio 千葉大学, 大学院医学研究院, 准教授 (60437308)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 分子状水素 / cAMP / 交感神経受容体 / β受容体 / GPCR

Outline of Final Research Achievements

This research project was aimed to investigate the mechanism by which molecular hydrogen (H2) has a potential to accelerate the beta-receptor signal. The real-time measurement system of intracellular cAMP was employed to evaluate the receptor signal. H2 showed synergistic action on the beta and calcitonin receptors, respectively. The site of action was indicated on the receptor. However, the fact that the effective range of H2 was extremely narrow suggests the requirement of a delicate control system of H2 to appreciate H2 actions. The effect of H2 on the receptor is slight compared to other pharmaceutical drugs.

Free Research Field

ガス薬理学