Development of probes for cancer theranostics based on photoacoustic effect and application for innovative DDS

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15316
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Sano Kohei 神戸薬科大学, 薬学部, 講師 (00546476)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ドラッグデリバリー / 光音響 / セラノスティックス

Outline of Final Research Achievements

In order to　develop　molecular　probes　enabling　cancer-targeted　photoacoustic imaging and cancer therapy, we newly synthesized trastuzumab (anti-HER2 monoclonal antibody)-conjugated liposome containing iron oxide nanoparticles (IONP) (Tra-IONP-liposome). The observation using transmission electron microscopy revealed many IONPs were encapsulated in the aqueous phase of liposomes. The Tra-IONP-liposome exhibited the intense photoacoustic signals, and could bind HER2-positive cancer cells HER2-specifically. Furthermore, this probe produced heat enough for cytotoxicity effect by irradiation of near-infrared light.

Free Research Field

分子イメージング、放射線科学