Pathophysiology of kidney diseases based on amino acids and related biomarker development

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15326
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: Wada Takashi 金沢大学, 医学系, 教授 (40334784)
• Co-Investigator(Kenkyū-buntansha): 古市 賢吾 金沢大学, 附属病院, 准教授 (50432125)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: キラルアミノ酸 / 慢性腎臓病 / バイオマーカー

Outline of Final Research Achievements

The number of patients suffering from chronic kidney disease (CKD), which is a risk factor for end-stage kidney disease resulting in requirement for renal replacement therapy is increasing all over the world. To overcome CKD, the establishment of adequate clinico-pathological parameters and related biomarkers for diagnosis and/or prediction for prognoses is required. Recent advances in research have shed light on the chirality of amino acids. The two-dimensional (2D) HPLC technique reveals that free D-amino acids and their L-forms are quantified quantitatively. In this study, we aimed to examine the pathophysiology of kidney diseases depending on amino acids and related relevant biomarker candidates for chronic kidney disease. As a result, we determined biomarker candidates, which were associated with the progression of chronic kidney disease.

Free Research Field

腎臓内科学