2017 Fiscal Year Final Research Report
Development of diagnostic kit for myelodysplastic anemia
| Project/Area Number |
16K15329
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石山 謙 金沢大学, 附属病院, 講師 (60377380)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 骨髄異形成症候群 / バイオマーカー |
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| Outline of Final Research Achievements |
Myelodysplastic syndromes (MDS) are the group of clonal myeloid neoplasms characterized by dysplasia of all kinds of hematopoietic cells and ineffective hematopoiesis. Twenty to thirty percent of MDS patients transform into acute leukemia.
To approach the ineffective hematopoiesis status in MDS patients, we focused on late stage of hematopoiesis and established the flow cytometry method. With this methods, we found the activin receptor type 2B (ACVR2B) as a biomarker for immature erythroid cells based on a sequence of microarray array analysis followed by qPCR validation in those fractions.
It is described that the percentage of ACVR2B-expressing cells was higher in peripheral blood of MDS patients than that of controls (normal subjects).
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| Free Research Field |
血液内科学
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