Does osteocalcin, a bone formation marker, predict future development of diabetes mellitus? A large-scale cohort study

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15360
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kindai University
• Principal Investigator: IKI Masayuki 近畿大学, 医学部, 教授 (50184388)
• Co-Investigator(Kenkyū-buntansha): 由良 晶子 近畿大学, 医学部, 講師 (80142595) ; 玉置 淳子 大阪医科大学, 医学部, 教授 (90326356)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: オステオカルシン / 低カルボキシル化オステオカルシン / 糖尿病 / コホート研究 / リスク予測

Outline of Final Research Achievements

Impaired glucose tolerance was observed in osteocalcin(OC)-deficient mice and was prevented by administration of osteocalcin to the animal. Inversed association between serum OC levels and glycemic indices were reported from cross-sectional studies of humans. We investigated the relationship of serum OC levels to subsequent risk of developing diabetes mellitus (DM). We observed decreased risk of DM by 10% per 1 SD increase in OC levels at baseline, but this decrease in risk was not statistically significant. The statistical power was not sufficient to find this small change in risk to be significant in this study. Studies in a larger scale would be necessary.

Free Research Field

疫学、公衆衛生学