PM protein 1 may be one of transboundary environmental factor.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15373
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Okayama University
• Principal Investigator: ogino keiki 岡山大学, 医歯薬学総合研究科, 教授 (70204104)
• Co-Investigator(Kenkyū-buntansha): 長岡 憲次郎 岡山大学, 医歯薬学総合研究科, 助教 (40752374) ; 江口 依里 岡山大学, 医歯薬学総合研究科, 助教 (60635118) ; 伊藤 達男 岡山大学, 医歯薬学総合研究科, 助教 (80789123)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: PM protein1 / PM protein 2 / PM2.5 / transboundary factor

Outline of Final Research Achievements

PM protein1 augmented PM2.5-induced airway inflammation, and PM protein2 lonely induced airway inflammation. It was suggested that PM protein might have a role in entry of PM, diameter below 0.1 mm. PM protein1 was detected in PM2.5 by immunoblotting, and approximate atmospheric concentration of PM protein1 was to be 1-2 ng/m3. An ELISA of PM protien1 in PM2.5 showed one peak from Jan. to Mar. Regression analysis showed PM protein1 was negatively associated with humidity, and the association of PM protein with humidity was independent. Taken together, PM protein1 exists in PM2.5, and PM protein1 elevated in winter season with low humidity and low temperature, and PM protein1 may be independent transboundary environmental factor.

Free Research Field

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