2017 Fiscal Year Final Research Report
Development of the cancer preventive strategy against a newly identified risk factor
| Project/Area Number |
16K15377
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hygiene and public health
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Iizumi Yosuke 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20533178)
|
|---|
| Research Collaborator |
Imai Ayaka 京都府立医科大学, 大学院医学研究科, 大学院生
Goi Wakana 京都府立医科大学, 大学院医学研究科, 研究補助員
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | APOBEC3B / がん予防 / 天然化合物 / スクリーニング |
|---|
| Outline of Final Research Achievements |
As an achievement of cancer genome projects, a cellular enzyme, APOBEC3B, has been reported to be a critical cause of mutations found in various cancers. In this study, we performed the screening for natural compounds which contribute to cancer prevention by decreasing APOBEC3B. As a result, we found two natural compounds which can downregulate APOBEC3B at the mRNA level, whereas these compounds could not decrease APOBEC3B at the protein level.
|
| Free Research Field |
がん予防
|
