Evaluation of toxicity of organic arsenic compounds in marine products used for Japanese food and search of toxicity-reducing

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15382
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: TAKATA Ayako 聖マリアンナ医科大学, 医学部, 教授 (30321897)
• Co-Investigator(Kenkyū-buntansha): 人見 敏明 聖マリアンナ医科大学, 医学部, 准教授 (90405275)
• Research Collaborator: YAMAUCHI Hiroshi 聖マリアンナ医科大学, 医学部, 客員教授 (90081661) ; CAO Yang 聖マリアンナ医科大学, 医学部, 助教 (70793751)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ヒ素 / 有機ヒ素化合物 / アルセノシュガー / 脂質性ヒ素 / 和食 / 安全性 / 毒性軽減 / 脳機能障害

Outline of Final Research Achievements

In recent years, brain dysfunction due to inorganic arsenic (iAs) exposure to low-age people is concerned. On the other hand, arsenolipids is contained in seafood used for Japanese food, and arsenosugars and arsenolipids are also contained in seaweeds. There are many isomers in these organic arsenic compounds (organic-As). Organic-As have limited informations on biological effects compared to iAs. In particular, it is considered that research to elucidate the biological effects of organic-As exposure on pregnant women and infants is an urgent task.
In this study, it can be inferred that there are many types of organic-As and it is difficult to carry out in animal experiments, and furthermore, preparation of a large amount of test samples becomes a problem. From this background, we clarified the basis for which the creation of a technique to evaluate brain dysfunction by a new cytotoxicity test method is required.

Free Research Field

予防医学