Role of the sympathetic nervous system in metastasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15417
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Ieguchi Katsuaki 東京女子医科大学, 医学部, 助教 (90586348)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 交感神経 / 転移 / 炎症性サイトカイン / 転移前微小環境

Outline of Final Research Achievements

The researcher investigated the functional relationship between the sympathetic nervous system and metastasis. The researcher found that the sympathetic nervous system partially contributed to angiogenesis, cell proliferation, and establishment of pre-metastatic niche in lungs. Moreover, tyrosine hydroxylase-positive neurons physically interacted with immunocompetent cells, and beta adrenergic agonists induced gene expression of inflammatory cytokines.

Free Research Field

分子細胞生物学