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2017 Fiscal Year Final Research Report

New classification of hepatocellular carcinoma by single cell analysis of immunome

Research Project

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Project/Area Number 16K15425
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKanazawa University

Principal Investigator

Mizukoshi Eishiro  金沢大学, 医学系, 准教授 (90345611)

Research Collaborator KISHI HIROYUKI  
HONDA MASAO  
YAMASHITA TARO  
HASHIMOTO SHINICHI  
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords細胞傷害性T細胞 / ヘルパーT細胞 / 免疫治療 / 免疫応答 / T細胞レセプター / 免疫細胞プロファイル / 制御性T細胞 / 抗腫瘍免疫
Outline of Final Research Achievements

In this study, we identified that the type and expression levels of immune molecules expressed in tumor infiltrating immune cells are different in each hepatocellular carcinoma (HCC) patient. We also identified that the differences are deeply associated with the etiology of HCC and the expression levels of many immune molecules in non-alcoholic steatohepatitis (NASH)-related HCC patients are lower than those in hepatitis B or C-related HCC patients. In addition, immune cell profiles are also different in the 3 groups. The frequency of tumor-associated antigen-specific T cells is lower in NASH-related HCC patients compared with that of other 2 groups and it is correlated with the specific immune cell profiles.

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Published: 2019-03-29  

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