2017 Fiscal Year Final Research Report
Establishment of human pluripotent stem cell-derived bile ductal disease analysis system using microfluidic device
Project/Area Number |
16K15434
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Tokai University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Keywords | ヒト多能性幹細胞 / 肝分化 |
Outline of Final Research Achievements |
The liver is the central organ of maintenance of the metabolism of the living body, and a method of reconstituting the mini-liver from human pluripotent stem cells in vitro has been developed. On the other hand, it has a disadvantage that it does not have a structure of the functional bile duct network which is important for the function of the liver. In this study, we are developing a culture system that can be applied to the analysis and treatment of human bile duct disease, by constructing a system that induces bile duct like structures from human iPS cell-derived hepatic progenitor cell. We also analyzed about the efficient culture system of mini-liver tissue using fluid devices.
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Free Research Field |
肝細胞生物学
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